Considered one of the best-known cannabis molecules, cannabidiol (CBD) is quickly becoming more popular thanks to its numerous therapeutic virtues. However, a question arises regarding its interaction with other medications, including acetylsalicylic acid, commonly known as aspirin. In this article, let’s explore together the points of convergence and divergence between these two substances.
What is CBD?
Cannabidiol, or CBD, is a non-psychoactive active component of Cannabis sativa. Unlike THC, it does not cause a high, it being part of the cannabinoid family which acts on the endocannabinoid system of our body. Among the many benefits attributed to CBD, we find in particular:
- Pain relief
- Relaxing and anti-stress effects
- Help with anxiety management
- Anti-inflammatory
- Potential anticancer effects
Its use has been widely popularized in the form of various products such as CBD oil, topical creams, capsules, e-liquids for electronic cigarettes and even CBD-infused foods.
What is acetylsalicylic acid?
Acetylsalicylic acid, better known as aspirin, is a medication with analgesic and anti-inflammatory properties. It is commonly used to treat mild to moderate pain, reduce fever, and prevent cardiovascular problems. Aspirin’s action relies primarily on its ability to inhibit the production of prostaglandins, chemicals responsible for inflammation, fever and the transmission of pain signals.
Mechanisms of action of CBD and acetylsalicylic acid
Interestingly, both CBD and acetylsalicylic acid are involved in some similar biological mechanisms. Indeed, CBD works in part by inhibiting the reuptake and breakdown of anandamide, an endocannabinoid that stimulates the production of prostaglandins. This leads to an increase in the concentration of anandamide, which helps to dull the perception of pain and reduce inflammation.
For its part, aspirin also blocks the formation of prostaglandins, but by a different mechanism: it prevents their synthesis by inhibiting the action of cyclooxygenase (COX), a key enzyme in this process. Thus, the two substances appear to act synergistically to combat inflammation and pain.
Research still in its infancy
Studies regarding the interaction between CBD and acetylsalicylic acid are still limited, but preliminary data suggests that their combination may provide some benefits. For example, a study conducted on rats in 2017 showed that the joint administration of CBD and aspirin was able to potentiate the antinociceptive effects of aspirin (i.e., reduce sensitivity to pain ). However, it should be kept in mind that these results cannot be directly extrapolated to humans and that more research is needed to confirm these initial observations.
Precautions and Recommendations for CBD and Aspirin Users
When it comes to combining CBD with medications such as acetylsalicylic acid, it is crucial to consult a healthcare professional, who will be able to assess each particular situation and give personalized advice. Indeed, current information does not make it possible to determine whether this synergy can be beneficial or, on the contrary, cause undesirable side effects for certain people with specific health problems or under drug treatment.
In addition, it is essential to choose quality CBD products that meet standards regarding their cannabinoid composition, particularly with regard to THC content. The presence of this psychoactive molecule in certain CBD products can cause unforeseen interactions with other medications and cause positive saliva tests for cannabis. To avoid any risk, always opt for serious suppliers with clear traceability on their items.
To conclude, the cross-effects between CBD and acetylsalicylic acid are still poorly understood, but current data suggests that their interaction could potentially provide benefits, particularly in terms of combating inflammation and pain. However, we must remain cautious about these results, because they do not constitute a solid basis for systematically recommending the combination of these two substances. Each case must be considered individually, with the support of a competent healthcare professional who is attentive to the specificities of the patient concerned.
